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Evolutionary Coupling Analysis

Predicted and experimental contacts

Interactive contact map

Secondary structure from ECs

Known pdb structures

pdb chain
2ens A
2le9 A
2lmb A

EC score distribution and threshold

Top ECs

Rank Residue 1 Amino acid 1 Residue 2 Amino acid 2 EC score
1 342 A 346 G 1.37
2 341 L 345 L 1.30
3 344 A 348 L 1.15
4 298 T 313 S 1.08
5 345 L 349 G 1.00
6 343 L 347 I 0.97
7 304 T 309 G 0.94
8 296 Q 318 I 0.89
9 298 T 315 A 0.86
10 360 V 364 Q 0.86
11 359 G 363 W 0.85
12 297 G 301 C 0.82
13 340 T 344 A 0.77
14 358 I 362 L 0.76
15 300 S 311 Q 0.74
16 300 S 313 S 0.71
17 362 L 366 R 0.71
18 302 V 309 G 0.69
19 347 I 351 L 0.68
20 302 V 311 Q 0.68
21 361 I 365 R 0.68
22 377 E 381 E 0.67
23 323 P 328 P 0.63
24 374 K 380 E 0.62
25 334 G 338 L 0.61
26 291 I 296 Q 0.60
27 375 A 379 Q 0.59
28 346 G 350 G 0.58
29 363 W 367 Q 0.56
30 365 R 369 R 0.55
31 288 L 295 D 0.55
32 373 R 377 E 0.53
33 323 P 327 G 0.51
34 303 A 310 P 0.51
35 371 E 376 P 0.50
36 376 P 380 E 0.50
37 296 Q 315 A 0.50
38 374 K 379 Q 0.49
39 373 R 378 N 0.46
40 349 G 353 T 0.45
41 375 A 381 E 0.45
42 376 P 381 E 0.44
43 370 G 378 N 0.44

Alignment robustness analysis

First most common residue correlation

Second most common residue correlation

Robustness